This solely depends in the situation, of whether this is for an Investor, Owner / User or Tenant. Businesses, whether Retail, Medical, Industrial or others, need to make sure that the Lease Structure protects the Business with the ability of a long term lease with pre-established renewals. Investing in the purchase of property can be a more lucrative, whereas the Business Owner can own the property and lease back to his own business. Each situation is different and it is always beneficial to seek advice from your CPA and Attorney.